Copper-catalyzed electrophilic amination of diorganozinc reagents

ORGN 298

Jeffrey S. Johnson and Ashley M. Berman. Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290
The copper catalyzed electrophilic amination of diorganozinc reagents employing O-acyl N,N-dialkyl hydroxylamine derivatives as aminating agents is described. This reaction offers a general method for the preparation of tertiary amines in high yields, and is noteworthy for its convenience both in terms of reaction conditions employed (room temperature, 1 hour) and ease of product isolation (acid/base extractive work-up).

 

New Reactions and Methodology
8:00 AM-12:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- 201A, Oral

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004