Trifluoroacetylation of amino acids under Schotten-Baumann conditions using a readily prepared non-odoriferious reagent

ORGN 611

Matthew R. Hickey, Todd D. Nelson, Elizabeth A. Secord, Shawn P. Allwein, and Michael H. Kress. Department of Process Research, Merck Research Laboratories, 466 Devon Park Drive, WYN-3, Wayne, PA 19087
The synthesis and application of S-dodecylthioltrifluoroacetate is described. Preliminary applications in Schotten-Baumann trifluoroacetylation reactions will be presented. Boasting similar reactivity and application as S-ethylthioltrifluoroacetate, this longer chain derivative is easily synthesized from cheap starting materials, has no detectable odor and is stable at room temperature.

 

New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004