Recent developments in dynamic kinetic resolution of alcohols employing a ruthenium racemization catalyst together with an enzyme

ORGN 110

Belén Martín–Matute, Michaela Edin, Krisztián Bogár, and Jan E. Bäckvall. Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, SE–106 91 Stockholm, Sweden
The combination of a biocatalyst and a chemocatalyst in one pot leads to deracemization via dynamic kinetic resolution (DKR). This presentation will describe novel developments that resulted in a very effective DKR of alcohols by combining an enzymatic resolution and a ruthenium-catalyzed racemization. The in situ coupling of these two processes resulted in an enantioselective synthesis of acetates in excellent yields at room temperature with very short reaction times. Mechanistic implications of our findings will be highlighted.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004