ORGN 573 |
| David B. Berkowitz, Kannan R. Karukurichi, Sangeeta Dey, Gourhari Maiti, and Weijun Shen. Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304 |
| Earlier we reported upon a method for screening catalysts wherein the (by)product of the organic reaction of interest is detected enzymatically. Biphasic conditions were employed, with the organic reaction taking place in an organic solvent, and the enzymatic reporting reaction occurring in a neighboring aqueous layer. This allows the enzymatic reporting reaction to be conveniently observed by UV/vis spectrophotometry, and provides for an estimate of the relative rates of reaction for a series of catalysts being screened in parallel. We termed this method In Situ Enzymatic Screening (ISES). In this presentation, we present newer results in which we seek to apply this approach to the study of asymmetric catalysis. Here, one seeks to glean information about both relative rate and relative stereoselectivity, for an array of catalysts under study. |
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New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |