Enantioselective H-atom transfer reactions: A strategy to synthesize aldol products

ORGN 20

Kalyani Patil and Mukund P. Sibi. Department of Chemistry, North Dakota State University, Dunbar 354, Fargo, ND 58105
Recently, we have developed an enantioselective hydrogen atom transfer method to synthesize amino acids. We have now extended the strategy to Baylis-Hillman adducts to furnish aldol products in good yield and enantioselectivity. The results illustrate that the selectivity is dependent on the size of ester substituent and the smaller substituent provides better enantioselectivity.

 

Asymmetric Reactions and Syntheses
8:00 AM-12:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- 201A, Oral

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004