ORGN 398 |
Synthesis of Luotonin A and its analogs by radical cascade cyclization
| Dennis P. Curran and Raghuram S. Tangirala. Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260 |
| Luotonin A is a pyrroloquinazolinoquinoline alkaloid extracted from the Chinese medicinal plant Peganum nigellastrum by Nomura and coworkers in 1997. Luotonin A shows certain obvious structural similarities to camptothecin (CPT), the parent of an important class of anticancer agents. Luotonin A was also recently shown to mediate topoisomerase-I dependent cytotoxicity, akin to that shown by CPT. An approach to the synthesis of Luotonin A and its analogs using a radical cascade cyclization methodology will be presented. Rapid access to the analogs of Luotonin A using this approach allows for a quick study of its structure-activity relationships. 
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Total Synthesis, Process R&D, Combinatorial, Bioorganic, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- Hall D, Poster
Sci-Mix
8:00 PM-10:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- Hall D, Sci-Mix
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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