A stereoselective radical strategy leading to acetate and anti-propionate aldol-like products

ORGN 23

Jake Zimmerman and Mukund P. Sibi. Department of Chemistry, North Dakota State University, Ladd Hall, Fargo, ND 58105
We have previously demonstrated an unusual bond construction strategy leading to acetate aldol like products with high enantioselectivity using conjugate radical additions. We now wish to report a highly diastereo- and enantioselective radical strategy leading to anti propionate aldol like products. Details of these reactions along with stereochemical analysis will be discussed.

 

Asymmetric Reactions and Syntheses
8:00 AM-12:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- 201A, Oral

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004