ORGN 158 |
| Rachel Lerebours and Christian Wolf. Department of Chemistry, Georgetown University, 37th and "O" Streets, Washington, DC 20057 |
| Palladium-phosphinous acids POPd, POPd1, and POPd2 have been found to catalyze Stille, Heck, Hiyama, and Sonogashira coupling reactions with high yields. We have found that these catalysts effectively promote coupling reactions in water. Palladium-catalyzed and NaOH-promoted Hiyama and Sonogashira cross-coupling reactions using aryl bromides and chlorides in water will be presented. The coupling methods do not require additives such as surfactants or organic co-solvents and proceed under air, which greatly facilitates operation and catalyst handling. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |