ORGN 474 |
| Jessica M. Davis and Andrew D. Hamilton. Department of Chemistry, Yale University, 225 Prospect St, P.O. Box 208107, New Haven, CT 06520 |
| Alpha-helices on protein surfaces often mediate protein-protein, protein-DNA, and protein-RNA interactions. Mimicking α-helices with small molecules has been proven to be an effective means to disrupt these interactions. Our work focuses on the synthesis of small molecule mimetics of α-helices designed to disrupt protein function. Based on success with a terphenyl scaffold, novel α-helix mimetics employing biphenyl, bipyridine, and piperazine-pyrimidine scaffolds have been designed to mimic the i, i+1, and i+4 residues of the inhibitory α-helix of Vav, a protein involved in the signaling pathways that control proliferation, cytoskeletal growth, and apoptosis in lymphoid cells. Progress towards the synthesis of these small proteomimetics will be presented. |
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Total Synthesis, Process R&D, Combinatorial, Bioorganic, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |