ORGN 564 |
Progress toward the total synthesis of Hibarimicin B
| Kwangho Kim and Gary A Sulikowski. Department of Chemistry, Texas A&M University, P. O. Box 30012, College Station, TX 77842 |
| Hibarimicins A, B, C, D, and G are among the most complex aromatic polyketide dimeric microbial secondary metabolites isolated. In addition to unique structural features, the hibarimicins possess important biological activity, specifically inhibiting protein tyrosine kinase activity with little effect on protein kinases A and C. A common structural feature shared by HMP-Y1 and the more complex hibarimicins is the highly substituted AB and GH ring systems. In contemplating the development of a synthetic program directed toward the hibarimicins and related metabolites such as HMP-Y1 we considered the development of a highly substituted cis decalin 1. The details of synthesis of decalin 1 and further efforts to synthesize HMP-Y1 will be described. 
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