ORGN 301 |
| J. David Warren, Justin S. Miller, and Samuel J. Danishefsky. Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, and Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027 |
| A method is disclosed for the convergent synthesis of multiply glycosylated peptides. The approach centers on a novel technique for generating masked, complex oligosaccharide-containing glycopeptide acyl donors that are activated in situ and used directly in segment coupling with a second complex oligosaccharide-containing glycopeptide, resulting in a completely unprotected, bifunctional glycopeptide. The system demonstrates a minimum level of hydrolysis and epimerization at the C-terminal residue of the acyl donor during fully convergent segment coupling. |
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New Reactions and Methodology
8:00 AM-12:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- 201A, Oral
Division of Organic Chemistry |