ORGN 799 |
| David B. Engel and Donald W. Whisenhunt Jr. Combinatorial Chemistry Laboratory, General Electric Global Research, One Research Circle, Niskayuna, NY 12309 |
| The Six-Sigma quality methodology was successfully applied to optimize the synthesis of benzylphosphonic acid. The study was performed using a robotic workstation coupled with factorial design of experiments (DOE). Results indicated that reaction temperature was the most important factor compared to reaction time and agitation. The overall yield of the synthesis was increased from 65% to 94% with a process capability increment of 5.1 sigma. |
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Combinatorial, Parallel, and Solid-Phase Chemistry
1:00 PM-5:00 PM, Thursday, August 26, 2004 Pennsylvania Convention Center -- 202B, Oral
Division of Organic Chemistry |