Silanediol-based inhibitors of the metalloprotease anthrax lethal factor

ORGN 466

Madhusudhan Purushotham, Wondwossen D. Arasho, and Scott McN. Sieburth. Department of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122
The design and synthesis of silanediol based peptidomimetics as inhibitors of metalloproteases has been successfully applied to thermolysin and angiotensin-converting enzyme. Anthrax Lethal Factor (LF) is a metalloprotease that is produced by the bacteria Bacillus anthracis, and it is directly responsible for death of the infected organism. The design and synthesis of silanediol-based inhibitors of LF will be described.

 

Total Synthesis, Process R&D, Combinatorial, Bioorganic, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004