A mild protocol for the deoxygenation of alpha-hydrogen containing sulfoxides to the corresponding sulfides

ORGN 619

Gurpreet S. Bhatia and Piotr P. Graczyk. Department of Medicinal Chemistry, Eisai London Research Laboratories Limited, University College London, Gower Street, London, WC1E 6BT, United Kingdom
A mild method for the deoxygenation of alpha-hydrogen containing sulfoxides to sulfides is reported. This synthetically useful and operationally simple protocol derives mechanistically from the Swern oxidation methodology.