ORGN 736 |
Hydrogen bond surrogate approach for the synthesis of short α-helical peptides
| Paramjit S. Arora, Department of Chemistry, Department of Chemistry, New York University, 100 Washington Sq East, New York, NY 10003 |
| We are developing internally constrained short α-helical peptides as potential tools to probe protein-protein and protein-nucleic acids interactions. Our strategy for α-helix stabilization involves replacement of one of the main chain i and i+4 hydrogen bonds with a covalent linkage. The scope of this approach for the development of highly helical peptides as well as current and future applications of these constrained α-helices to modulate protein interactions will be discussed. 
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Proteins, Peptides, and Amino Acids
8:00 AM-12:00 PM, Thursday, August 26, 2004 Pennsylvania Convention Center -- 201A, Oral
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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