ORGN 429 |
Small molecule microarrays: New tools for building addressable libraries on a chip
| Eden Tesfu and Kevin D. Moeller. Department of Chemistry, Washington University in St. Louis, One Brookings Dr, Campus box 1134, St. Louis, MO 63130 |
| The poster presents new tools for building addressable libraries on programmable electrode-based chips. With the development of chemical genomics, there is a need to develop efficient ways to synthesize a variety of small molecule libraries. DNA and peptide libraries have been successfully built on the chip using electrochemically generated acids and bases. Can similar methods be used to construct diversity-oriented small molecule libraries? The answer to this question depends on the types of synthetic transformations that can be performed on the chips. For this reason, the application of transition metal-based synthetic methodology on a chip is being explored. As a first step the generation of Pd (II) reagents at preselected site is being studied. For example, an electrode-mediated Wacker-type reaction was accomplished site selectively on a chip. Adding ethyl vinyl ether on to the reaction solution ensured the confinement of the reagent to the pre-selected site. Studies to probe the scope of Pd (II)-mediated reactions that can be done on the chips are being pursued. 
|
| |
|
Total Synthesis, Process R&D, Combinatorial, Bioorganic, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- Hall D, Poster
Sci-Mix
8:00 PM-10:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- Hall D, Sci-Mix
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
|