ORGN 796 |
| Jordan Blodgett, Department of Chemistry, Vanderbilt University, Nashville, TN 37235 and Tingyu Li, Department of Chemistry, Mississippi State University, Box 9573, Mississippi State, MS 39762. |
| Since the practical synthesis of organic compounds is limited not only by yield of specific reactions but also by the ability to isolate products efficiently, various strategies to facilitate product isolation have been developed. Among them, syntheses using insoluble polymeric support are widely used for peptide, oligo-nucleotide, and small organic molecules synthesis in connection with high throughput synthesis. The limitations of this strategy are that many organic reactions must be re-optimized for solid phase synthesis, are difficult to monitor, and it is impossible to purify reaction intermediates. Another strategy involves solution phase synthesis on a soluble polymer tag, which have relatively low loading capacity due to the size of the tag. Recently, fluorous tags with affinity toward fluorous silica gel have attracted much attention. In this presentation, a new tagging system based on the interaction of beta-cyclodextrin and the 4-t-butylphenyl group will be described. |
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Combinatorial, Parallel, and Solid-Phase Chemistry
1:00 PM-5:00 PM, Thursday, August 26, 2004 Pennsylvania Convention Center -- 202B, Oral
Division of Organic Chemistry |