ORGN 194 |
Bottom-up construction of pure guanine DNA nanostructures using short oligonucleotide building blocks
| Dongsheng Liu1, Rachel McKendry2, and Shankar Balasubramanian1. (1) Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom, (2) The London Centre for Nanotechnology, Rayne Institute, University College London, 5 University Street, London, WC1E 6JJ, United Kingdom |
| In addition to carrying the genetic code for life, DNA has attracted considerable attention as a novel nanomaterial. Cubed, branched and knotted structures have been fabricated, guided by complementary Watson and Crick base pairing. However a range of more complex structures are also possible, using triple helical conformations or even four stranded arrangements, such as G-quadruplexes. Here we report the construction of linear DNA structures composed from purely guanine bases (termed G-wires), with no intermediate bases. These linear G-wires were made via the self-assembly of short building blocks containing only six guanine bases (G6: 5' GGGGGG 3') via purely G-quadruplex formation. This new type of DNA structure appears more thermal stable and rigid than previously reported constructs. 
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster
Sci-Mix
8:00 PM-10:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- Hall D, Sci-Mix
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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