ORGN 581 |
Nickel-catalyzed hydrophosphinylation
| Patrice Ribiere, Karla Bravo-Altamirano, Monika Antczak, Jennifer D. Hawkins, and Jean Luc Montchamp. Department of Chemistry, Texas Christian University, TCU Box 298860, Fort Worth, TX 76129 |
| A novel, cheap, and practical nickel-catalyzed hydrophosphinylation of unsaturated compounds is described which adds to the synthetic methods developed in our laboratory for the preparation of biologically-active monosubstituted phosphinic esters. The addition of alkyl hypophosphites to alkynes proceeds smoothly in moderate to good yields and does not require the use of additional ligands. The reaction conditions are very general and allow the use of fonctionalized substrates. Regio- and chemo-selectivity studies of the reaction are currently in progress in our laboratory. Our preliminary investigations will be discussed. 
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New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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