ORGN 577 |
| Jamie D. Knight1, Alan Armstrong1, and Lyn H. Jones2. (1) Department of Chemistry, Imperial College, South Kensington, Exhibition Road, London, SW7 2AZ, United Kingdom, (2) Pfizer Ltd, IPC 424, Ramsgate Road, Sandwich, Kent, United Knigdom, CT13 9NJ, IPC 424, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom |
| Electrophilic amination provides a conceptually powerful means for the incorporation of nitrogen into molecular frameworks. Nitrogen-containing functional groups are prominent amongst bioactive compounds, making methods for their selective introduction of fundamental importance in organic synthesis. Recently we have discovered novel electrophilic aminating agents that offer extremely effective heteroatom transfer with a range of nucleophiles. We will summarize our findings and subsequent applications to heterocyclic synthesis. |
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New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry |