Asymmetric synthesis of (R)-(+)-4-aminocyclo-pentenone using olefin-enone ring-closing metathesis (RCM)

ORGN 116

Franklin A. Davis and Yongzhong Wu. Department of Chemistry, Temple University, Beury Hall, 13th and Norris Streets, Philadelphia, PA 19122
(R)-(+)-Aminocyclopentenone 3 is a valuable chiral building block for the asymmetric synthesis of structurally diverse antiviral and anticancer carbocyclic nucleosides. An efficient synthesis of 3 using olefin-enone ring-closing metathesis of amino keto-2,7-dienes 2 will be presented.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004