Vitamin D side chain triazole analogs via cycloaddition "click" chemistry

ORGN 128

Byung Chul Suh, Heung Bae Jeon, Gary H. Posner, and Steven M. Silverman. Department of Chemistry, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
1,3-Dipolar cycloaddition of a vitamin D side chain terminal acetylene with phenyl azide and separately with a vitamin D side chain terminal azide produced the corresponding 1,2,3-triazole monomeric and dimeric analogs of 1a-hydroxyvitamin D3 in good yields.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004