ORGN 291 |
| Israel Garcia and Luis E. Martinez. Department of Chemistry, University of Texas at El Paso, 500 West University Ave., El Paso, TX 79968 |
| Fischer carbene complexes have been used extensively to synthesize substituted naphthoquinones via the Dötz benzannulation. We report the solid phase organic synthesis of polymer supported Fischer carbene complexes and their thermal benzannulation to generate small libraries of 2,3-disubstituted naphthoquinones. Microwave irradiation was found to be more effective than traditional thermal heating. Various reaction optimization factors such as the nature of the polymer and oxidizing agent will also be presented. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |