ORGN 114 |
| Anusha Vable, Department of Chemistry, Grinnell College, Grinnell, IA 50112-1690 and Wayland E. Noland, Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455. |
| The purpose of this work is to synthesize compounds that are active against tuberculosis. To make molecules hoped to be active, indole (1) was dimerized to (2). Two synthetic routes were tried after the initial step, one in which an acyl group was introduced while the indole dimer was a hydrochloride salt (2), and another where the acyl groups were introduced after the indole dimer was deprotonated (4). In all cases, the acyl groups were attached to the indoline nitrogen to form acyl derivatives 3 and 5. The compounds will be offered to the Southern Research Institute (contractor for NIH) for testing against tuberculosis.
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New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |
