CHED 875 |
| Alexander J. Pickrell and Daniel J. O'Leary. Department of Chemistry, Pomona College, 645 North College Avenue, Claremont, CA 91711 |
| Hydrogen bonding plays a vital role in numerous biological and chemical reactions, as well as affecting conformations of various biochemical molecules. Various derivatives of myo-inositol monoorthoformate containing unique 1,3-diaxial intramolecular hydrogen bonding networks have been prepared for NMR analysis. We have synthesized and analyzed a symmetric tetrol as well as a triol containing a network of OH/OH/OH hydrogen bonds. Specifically, titrations have been done in order to measure deuterium isotope effects in the proton NMR spectra. These titrations employ the addition of exchangeable deuterons and the hydrogen-bond mediated isotope effects arise as chemical shift perturbations in the hydroxyl resonances. Our preliminary measurements suggest that this approach can be used to detect a contiguous array of four hydroxyl groups. |
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Undergraduate Research Poster Session: Organic Chemistry
2:00 PM-4:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Chemical Education |