CHED 797 |
Approaches toward the synthesis of kasumigamide using solid-phase synthesis
| Rita S. Majerle, Amanda J. DeGraw, and Kiah Smith. Department of Chemistry, Hamline University, 1536 Hewitt Ave, St Paul, MN 55104 |
| Peptide based compounds have exhibited a range of biological activities having served as hypertensive agents to biocides. The isolation of the anti-algal compound kasumigamide from cyanobacterium Microcystis aeruginosa was recently reported. Kasumigamide and its analogs are attractive alternatives to many of the current algaecides that are available because of their specificity and very low toxicity. This tetra-amino acid compound which contains a novel amino acid has not been synthesized to date. Modeling studies of the peptide would provide site interaction information that could be useful in producing more potent biocides. We report here to date our solid-phase synthesis of kasumigamide and our initial modeling studies.  |
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