CHED 809 |
| Adrienne Bentley, Adrienne G. Davidson, and Joshua S. Sasine. Department of Chemistry, Georgia Institute of Technology, Atlanta, GA 30507 |
| The association of organic molecules through noncovalent interactions is becoming increasingly important for the development of novel structures for information storage, molecular transport, sensing and the assembly of supramolecular structures. Several calixarene derivatives propylated on the lower rim and variously substituted on the upper rim have been synthesized. Mixtures of these derivatized calixarenes with complementary functional groups form heterodimers through hydrogen-bonding and/or ion-pairing at their upper rims. By varying the identity of the functional groups on the upper rim, the size and the strength of the dimers can be manipulated. Encapsulation of organic guest molecules within the cavity of these dimers suggests their potential use as molecular capsules. In order for these capsules to be used for drug delivery, they must be water-soluble. To increase water solubility, calix[4]arene derivatives were synthesized with carboxylic acids, hydroxyethyls or sulfonates on the lower rim. |
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Undergraduate Research Poster Session: Organic Chemistry
2:00 PM-4:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Chemical Education |