CHED 792

Biologically active cytotoxic bromotyrosine alkaloids, suberedamines A (1) and B (2) were isolated from an Okinawan marine sponge, Suberea sp1. The synthesis of suberedamines A and B is going to be accomplished through the coupling of mono-brominated L tyrosine and di-brominated tyramine derivatives. Using the suberedamines A and B as starting materials, the natural products Ma’edamines A (3) and B (4) can be synthesized. This poster presentation will present the progress of our work toward the synthesis of the natural products, suberedamines A and B.

1: R=H

2: R=CH₃

3: R=CH₃

4: R=H