Synthesis of a novel isoxazolinone antibacterial agent

CHED 889

Kimberly A Gauquie and J. Thomas Ippoliti. Department of Chemistry, University of St. Thomas, 2115 Summit Ave, OSS 402, St. Paul, MN 55105
Antibacterial resistance is a continuing threat as many bacteria are becoming resistant to multiple treatments. Recently, a research group has developed a new class of antibacterial agents, known as isoxazolinones, for treatment against resistant strains of bacteria. A seven-step synthesis of a novel isoxazolinone is described. Products from the first five steps have been isolated and identified using proton NMR. The mechanisms and procedures of each step, as well as the data characterizing each purified intermediate, will be presented. The final two steps have yet to be completed.

 

Undergraduate Research Poster Session: Organic Chemistry
2:00 PM-4:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Hall A, Poster

Division of Chemical Education

The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004