ORGN 63 |
| Minoo Sedighi, Department of Chemistry, Department of Chemistry, Purdue University, West Lafayette, IN 47907 |
| A new method for the protection of carboxylic acids as their 1,1-dimethylallyl ester has been developed. This new protecting group is an alternative to the t-butyl ester for those acid sensitive substrates and provides protection against nucleophilic attack. The synthesis of this new protecting group is involves two steps. The first step is the esterification of acids to produce their alkynes form and the second step is the hydrogenation of the alkyne to form desired allyl ester. It is expected that this protecting group will find use in the synthesis of acid sensitive compounds such as cyclic peptides. |
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New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |