MEDI 2 |
| Stephen W. Kaldor, Syrrx, Inc, 10410 Science Center Drive, San Diego, CA 92121 |
| Considerable advances have been made over the last fifty years in determining the structures of proteins and other naturally occuring macromolecules, providing key insights into structure-function relationships. This has been complemented with a major thrust toward target and mechanism-based approaches to disease modulation. Despite these accomplishments, it is sobering to note that the structures of less than five percent of the known protein families in the human genome have been solved, and that very few drugs have been brought to the marketplace that are true products of structure-based drug discovery. It is interesting to examine our current ability to access and use macromolecular structure and to speculate on what the future will hold. The field of structure-based drug discovery will be used to illustrate opportunities for twenty-first century chemists to advance the basic science in the area of macromolecular structure and simultaneously have a pronounced positive impact on human health. |
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Challenges for the Chemical Sciences in the 21st Century: Health and Medicine
9:00 AM-12:30 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Ballroom D, Oral
Division of Medicinal Chemistry |