CHED 871 |
| Ryan P. Mynatt and Mark T. Blankenbuehler. Department of Physical Sciences, Morehead State University, Morehead, KY 40351 |
| There will always be a need for new pharmaceuticals as long as there are those that will be around to use them. In the area of inflammation relief and pain suppression the newest drugs on the market have a heterocycle of sulfur, oxygen, and nitrogen, and these drugs commonly use a pyrazole or a pyridazine central structure to enhance the pharmaceuticals biological activity inside the body. The purpose of these experiments is to synthesize hydroxyfulvene precursors to a cyclopenta[d]pyridazine structure. These pyridazines could be used as a possible pharmaceutical with uses ranging from a non-steroidal anti-inflammatory drug (NSAID) to an anticancer treatment. The final closing of the ring is done with a monosubstituted hydrazine to add the functional sulfonamide group into the fused cyclopenta[d]pyridazine structure and was attempted on some hydroxyfulvene products. Characterization of the hydroxyfulvenes was carried out using NMR and IR spectroscopy. |
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Undergraduate Research Poster Session: Organic Chemistry
2:00 PM-4:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Chemical Education |