ORGN 329 |
| Paul O'Brien1, Siobhan S. Cummins2, Dan Darcy3, Eric Liu4, Ombretta Masala4, Nigel L. Pickett1, Steve Ryley2, and Andrew J. Sutherland1. (1) Department of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom, (2) Department of Chemical Engineering and Applied Chemistry, Aston University, Aston Triangle, Birmingham, B4 7ET, United Kingdom, (3) Biological Imaging Center, California Institute of Technology, Pasadena, CA 91125, (4) Nanoco, 48 Grafton Street, Manchester, M13 9XX, United Kingdom |
| A novel approach for optically encoding polymeric solid phase synthesis resins with quantum dots is described. Quantum dots are an attractive proposition for fluorescence encoding techniques since they are very bright, photostable materials and importantly have narrow emission bands allowing several types to be combined to customise emission profiles. A number of polymerisable ligands have been synthesised which can be exchanged with the hexadecylamine capping ligands of the CdSe/ZnS quantum dots. Suspension bead polymerisation then results in beads containing covalently incorporated quantum dot fluorophores. Fluorescence profiles have been recorded by photoluminescence spectroscopy and fluorescence microscopy studies. On bead chemistry has been performed on a range of commonly encountered polystyrene resins with added quantum dots, to demonstrate their robustness to conditions commonly encountered during organic synthesis. Examples will be given of peptide coupling reactions with subsequent Fmoc release assays. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |
