ORGN 192 |
| Darryl Bornhop1, Charles Manning1, Tim Goebel1, Sarah Smith1, Michelle Sexton2, Reid Thompson3, Ron Price3, and Mahlon Johnson3. (1) Chemistry and Biochemistry, Texas Tech University, One Circle Dr, Lubbock, TX 79409, (2) Bastyr University, Seattle, WA, (3) Vanderbilt Medical Center, Nashville, TN 37232 |
| The synthesis and characterization of polyazamacrocyclic lanthanide chelate molecular imaging agents will be described. These new agents have bright luminescence, provide MRI contrast, have a long emission lifetime, can be used as a molecular-scale temperature or pH sensor, are non-toxic and can be tuned structurally for molecular recognition. The prospect of using lanthanide chelate MIs as dual imaging agents, for in-vitro diagnostics, in-vivo disease detection and for simultaneously monitoring and delivering therapeutic doses will be discussed. It will also be shown that when the peripheral benzodiazepine receptor (PBR) ligand PK-11195 is conjugated to our lanthanide chelate, the resulting compound (Ln-PK-11195) will act as a molecular signaling agent of the 18kD protein involved in steroidogenesis. The potential to perform bi-modal molecular imaging of cancer and CNS disease will be introduced, as will the potential to the further study mitochondrial function and its relationship to cancer cell proliferation.
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Chemistry and Biological Applications of Imaging Agents and Molecular Beacons
1:25 PM-5:10 PM, Monday, March 29, 2004 Anaheim Convention Center -- Ballroom C, Oral
Division of Organic Chemistry |