Development of a scalable route to a pyridoquinoxaline antiviral compound

ORGN 123

William R. Perrault, Paul M. Herrinton, Richard A. Hohler, Joseph W. Strohbach, Steven P. Tanis, and Malcolm W. Moon. Early Process Research and Development, Pharmacia, 7000 Portage Rd., Kalamazoo, MI 49004
A scalable route to a pyridoquinoxaline antiviral compound was developed which allowed for the rapid preparation of significant quantities of material to support development needs. A method of preparing the key heterocyclic ring was developed which involved a one step cyclization/ deacylation procedure.