Advances in the asymmetric construction of architecturally complex natural products: The Lituarines

ORGN 184

A.B. Smith III, Department of Chemistry, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323
The lituarines A, B, and C comprise a small class of highly complex, bioactive natural products isolated from the sea pen Lituaria australasae. Initial screening revealed significant cytotoxicity [IC50=1-9 nmol(KB cells)], however, the low natural abundance has hindered further biological evaluation. Recently we initiated efforts to develop a convergent, stereocontrolled synthesis of these novel macrolides. A summary of these results will be presented.

 

Ernest Guenther Award in the Chemistry of Natural Products
1:30 PM-4:55 PM, Monday, March 29, 2004 Anaheim Convention Center -- Bllrm A/B, Oral

Division of Organic Chemistry

The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004