ORGN 406 |
| Subodh Dutta1, Varangati Shankar2, and Subra Muralidharan1. (1) Department of Chemistry, Western Michigan University, Kalamazoo, MI 49008, (2) Chemistry, Western Michigan University, Kalamazoo, MI 49008 |
| Prostaglandins are interesting biomolecules as they can be markers for the onset of diseases. For example the prostaglandin PGE2 is often a marker for such ailments as gum disease, cervical cancer, and arthritis. Clearly a practical PGE2 sensor will have wide clinical diagnostic applications. We are investigating the design, synthesis, and characterization of PGE2 nanosensors based on luminescence changes. The sensing systems that will be reported in this talk are a family of novel luminescent chiral ruthenium (II) complexes. The molecular dimension of these molecules are in the nanometer scale and the sensing mechanism is based on the interaction of the chiral centers on the Ru(II) molecules with the chiral centers of PGE2. These molecules have been characterized by x-ray crystal structure, optical activity, and multinuclear NMR. A critical component of these studies is the characterization of the sensitivity and selectivity of the sensing molecules for the target PGE2 molecules from complex matrices such as biological fluids. The interaction of the Ru(II) nanocomplexes with PGE2 under a variety of conditions has been characterized by uv-visible and emission studies. The emission studies have been conducted at various temperatures to derive lifetimes of the excited states and the activation parameters to gain a fundamental understanding of the interactions of the sensing molecules with PGE2. The optimization of these interactions to amplify luminescence changes based on the three-point principle and the incorporation of the nanomolecules into polymeric matrices will be discussed. |
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Materials, Devices, and Switches
8:00 AM-12:00 PM, Wednesday, March 31, 2004 Anaheim Convention Center -- 303A, Oral
Division of Organic Chemistry |