Progress toward the total synthesis of pancratistatin and related compounds

ORGN 441

Bruce P. Branchaud and Steven R. Woodcock. Department of Chemistry, University of Oregon, Eugene, OR 97403-1253
The Amaryllidaceae alkaloids exhibit significant antitumor activity. As a group they are structurally complex with a variety of functionality. (+)-Pancratistatin is the most promising member of this class of alkaloids. Several multi-step syntheses of pancratistatin have been reported. Recent progress towards the synthesis of pancratistatin and deoxypancratistatin from cheap, readily available starting materials will be presented.

 

Total Synthesis, Asymmetric Reactions and Syntheses, Bioorganic
9:00 AM-11:00 AM, Wednesday, March 31, 2004 Anaheim Convention Center -- Hall C, Poster

Division of Organic Chemistry

The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004