ORGN 340 |
| Punitha Vedantham, Department of Chemstry, University of Kansas, 1251 Wescoe Hall Dr, Lawrence, KS 66045-7582, Daniel L. Flynn, Neogenesis Pharmaceuticals, Inc, 840 Memorial Drive, Cambridge, MA 02139, and Paul R. Hanson, Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr, Lawrence, KS 66045-7582. |
| A general ring-opening metathesis (ROM) polymerization approach to an array of high-load nucleophile and electrophile scavengers for facilitated synthesis protocols will be presented. We have generated functionalized norbornenyl-based monomers and subjected them to ROM polymerization utilizing a panel of metathesis catalysts to provide high-load oligomers of varying lengths and solubility profiles. These scavengers can be introduced after completion of reaction, effectively removing excesses of reagents or spent reagents. The spent/unspent oligomers are then either precipitated or filtered away to furnish the desired compounds in excellent yields and purities. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |