ORGN 443 |
Progress toward the total synthesis of the antimalarial bisindole alkaloid villastonine
| Jun Ma, Chunchun Zhang, Jianming Yu, and James M. Cook. Department of Chemistry, University of Wisconsin-Milwaukee, 3210 N. Cramer Street, Milwaukee, WI 53201 |
Villalstonine is a bisindole formed from the stereospecific condensation of the monomeric indole alkaloids macroline and pleiocarpamine. It has been ioslated from several Alstonia species and has been shown to exhibit antiplasmodial activity. It is much more potent than the corresponding monomeric units against Plasmodium falciparum malaria. An approach towards the total synthesis of villastonine via a Ni catalyzed coupling reaction will be presented.  |
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Total Synthesis, Asymmetric Reactions and Syntheses, Bioorganic
9:00 AM-11:00 AM, Wednesday, March 31, 2004 Anaheim Convention Center -- Hall C, Poster
Division of Organic Chemistry
The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004
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