ORGN 307 |
| Sriram Kanvah, School of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State Street, Atlanta, GA 30332 and Gary B. Schuster, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State Street, Atlanta, GA 30332. |
| DNA is the vehicle for inheritance in cellular life, and for this reason understanding the processes that damage DNA causing mutations is important. Subsequently, its repair takes on great importance. Irradiation of an anthraquinone-linked DNA duplex generates a base radical cation that migrates through the duplex inducing damage selectively at GG step. It has been suggested that evolutionary pressure for preservation of genomic integrity would generate ‘hole sinks’ optimized to bind to DNA and neutralize base radical cations inhibiting the guanine damage and hence mutations. Investigations towards manipulation of structural and binding properties of DNA lead to certain sacrificial reagents which can act as appropriate ‘hole sinks’ thus protecting the DNA from damage. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |