ORGN 281 |
| Jonathan M. Collins and C. Fred Hassman III. Life Sciences Division, CEM Corporation, 3100 Smith Farm Road, Matthews, NC 28106 |
| While Solid Phase Peptide Synthesis has become a powerful and widespread technique that has seen much improvement, there still exists many peptides that are extremely difficult the synthesize. Difficult peptides are often attributed to formation of secondary structures and aggregation that leads to incomplete deprotection and coupling reactions. Microwave energy represents a new route of applying energy at the molecular level that can help drive difficult reactions to completion much faster than conventionally possible. In this paper some of the most extremely difficult peptide sequences, including the notoriously difficult polyalanine sequences were synthesized with microwave energy and compared to conventional methods. Comparisons were performed using different resins, activators, and varying excess reagents.
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Proteins, Peptides, Amino Acids, and Nucleotides
1:00 PM-5:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- 303D, Oral
Division of Organic Chemistry |