ORGN 303 |
| Huachuan Cao, School of Chemistry & Biochemistry, Georgia Institute of Technology, 770 State Street, Atlanta, GA 30332 and Gary B. Schuster, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State Street, Atlanta, GA 30332. |
| As a hydrophilic biopolymer, a DNA molecule is surrounded by water molecules in aqueous solution. The mechanism of charge hopping in DNA indicates the competition between cation quenching by water molecules and cation migration and trapping at guanines partially determines the distance and efficiency of charge transport in DNA. We synthesized a series of DNA binding lipids which possess high DNA binding affinity due to their multi-charged spermine head-groups. Even though no significant conformation distortion was observed for DNA/lipid complex in characterization experiments, UV-induced oxidation damages were significantly reduced in DNA/lipid complexes. The effect of water molecules on charge transport was studied by comparison between DNA and DNA-lipid complexes. We proposed that the variation of water and sodium ion distribution in the DNA grooves and formation of lipid bilayer surrounding DNA leads to the reduced damage at guanine bases. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |