ORGN 496 |
| Alison McCurdy, Rex Cheng, and Ronald W. Tan. Department of Chemistry and Biochemistry, CSU Los Angeles, 5151 State University Dr, Los Angeles, CA 90032 |
| Understanding the subtleties in protein structure and stability is important in many biochemical and medical applications. Specifically, side chain interactions have been found to play a role in the stability of α-helices. The nature of side chain interactions between aromatic residues and cations is not yet fully characterized. This cation-pi interaction has been documented in both artificial and natural systems. In this work, the strength of two cation-pi interactions (trp-arg, tyr-lys) in an alanine-based model helix will be assessed using circular dichroism (CD). Relative stabilities of peptides with residues spaced (i, i+4) and (i, i+5) will be determined using thermal and denaturant unfolding curves. |
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Total Synthesis, Asymmetric Reactions and Syntheses, Bioorganic
9:00 AM-11:00 AM, Wednesday, March 31, 2004 Anaheim Convention Center -- Hall C, Poster
Sci-Mix
Division of Organic Chemistry |