ORGN 18 |
| Xiaoxia Zhang and Richard C. Larock. Department of Chemistry, Iowa State University, Ames, IA 50011 |
| The reaction of N-(2-alkynyl)-N-(4-methoxyphenyl)triflamides or acetamides with ICl at –78 oC affords substituted spirodienones. The steric and electron effect of the substrates on the triple bond of the alkynyl amides has been studied. Aryl-, vinylic-, sily-, and alkyl-substituted acetylenes undergo this cyclization to produce iodo-substituted spiro compounds in excellent yields. |
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New Reactions and Methodology
8:00 AM-12:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- 303A, Oral
Division of Organic Chemistry |