ORGN 423 |
| Wei Han, Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, Sumneytown Pike, West Point, PA 19486 and Edward R. Biehl, Department of Chemistry, SMU, Dallas, TX 75275. |
| Some quissinoid compounds inhibited whole cell protein synthesis of P-388 cells. A series of experiments were conducted by many biologists to establish the inhibition mechanism by some quissinoid compounds in the P-388 leukemia cell. For this series of pharmacologically active natural products many synthetic researches were performed. However, a practical and convergent synthesis of the core structure is still needed to be developed. The modification of the core structure is still an interesting research field. A novel convergent strategy to the construction of the quissinoid skeleton is described. Our strategy disconnects the molecule into two functional fragments. Two advanced intermediates have been synthesized. It is hoped that the synthetic route can be adapted to enable the construction of quissinoid skeleton. Synthetic progress to date will be covered. |
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Total Synthesis, Asymmetric Reactions and Syntheses, Bioorganic
9:00 AM-11:00 AM, Wednesday, March 31, 2004 Anaheim Convention Center -- Hall C, Poster
Division of Organic Chemistry |