ORGN 527 |
| Doss Jayaprakash, Shinobu Takizawa, Takayoshi Arai, and Hiroaki Sasai. ISIR, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka, 567-0047, Japan |
| Previously we have developed multifunctional asymmetric catalysts (MACs), such as La-Li3-tris(binaphthoxide) (LLB) and Al-Li-bis(binaphthoxide) (ALB) which exhibited enzyme like activity in some reactions. If MACs are immobilized on polymer supports, insoluble catalysts could be obtained as useful and reusable catalysts. However the random introduction of ligands and functional units onto a sterically irregular solid polymer backbone (e.g., polystyrene resin) was less effective for the immobilization of MACs due to the haphazard orientation of ligands and functional units on the support. To further the development of immobilized MACs, soluble polymers, dendrimers and dendronized polymers containing BINOLs were synthesized. Heterogeneous catalysts were easily generated with these supports and reused as catalysts with high enantiocontrol. New methods for constructing polymer supported catalysts based on the use of a ²catalyst analog² and insoluble metal-bridged polymer catalyst without using any support would also be discussed in this presentation. |
|
Asymmetric Reactions and Syntheses
1:00 PM-5:00 PM, Wednesday, March 31, 2004 Anaheim Convention Center -- 303D, Oral
Division of Organic Chemistry |
