Design and development of new polymer supported thiol reagents and their evaluation as palladium scavengers

ORGN 331

Michael Singer, Shigui Li, and Timothy B. Haney. Sigma-Aldrich Drug Discovery Research and Development Group, Sigma-RBI, 3 Strathmore Road, Natick, MA 01730

The use of polymer supported reagents as scavengers has been well demonstrated as an effective tool in organic synthesis. The use of polymer supported thiol resins have been shown to be effective as palladium scavenging reagent. We report here two new thiol resins for use as palladium scavengers. The synthesis and evaluation of these two new polymer supported thiol resins will be presented.

Physical Organic, Combinatorial, Materials, Molecular Recognition 8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster Division of Organic Chemistry The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004