ORGN 438 |
Synthetic studies toward the first naturally occurring glutamate receptor antagonist, Kaitocephalin
| Rishi G. Vaswani, Deparment of Chemistry, University of California, Irvine, Irvine, CA 92697 and A. R. Chamberlin, Department of Chemistry, University of California at Irvine, Irvine, CA 92697. |
As the first naturally occurring glutamate receptor antagonist, kaitocephalin provides a unique opportunity to further understand the role of (L)-glutamate in the mammalian CNS. This presentation will describe the progress toward the total synthesis of Kaitocephalin. Key transformations include the diastereoselective formation of a chiral substituted pyrrolidine ring and the stereoselective assembly of the C-4 quaternary center. To further elucidate the key structural features that contribute to antagonist activity, a small molecule library based on Kaitocephalin will also be described.  |
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Total Synthesis, Asymmetric Reactions and Syntheses, Bioorganic
9:00 AM-11:00 AM, Wednesday, March 31, 2004 Anaheim Convention Center -- Hall C, Poster
Division of Organic Chemistry
The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004
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