Mild and practical copper-catalyzed amination of unactivated halothiophenes

ORGN 95

Zhikuan Lu and Robert J. Twieg. Department of Chemistry, Kent State University, Kent, OH 44242
We have found that N,N-dimethylethanolamine (deanol) is a useful solvent for copper catalyzed amination of a variety of unactivated 2- or 3-halothiophenes. Primary amines, cyclic secondary amines and acyclic secondary amines with hydroxyethyl functionality react with halothiophenes in moderate to excellent yields. The mildly basic conditions utilized are compatible with many functional groups. Halobithiophenes have also been examined.

 

New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004